Efficacy of pentavalent rotavirus vaccine against severe rotavirus gastroenteritis in infants in developing countries in sub-Saharan Africa: a randomised, double-blind, placebo-controlled trial.
Identifieur interne : 000937 ( Main/Exploration ); précédent : 000936; suivant : 000938Efficacy of pentavalent rotavirus vaccine against severe rotavirus gastroenteritis in infants in developing countries in sub-Saharan Africa: a randomised, double-blind, placebo-controlled trial.
Auteurs : George E. Armah [Ghana] ; Samba O. Sow ; Robert F. Breiman ; Michael J. Dallas ; Milagritos D. Tapia ; Daniel R. Feikin ; Fred N. Binka ; A Duncan Steele ; Kayla F. Laserson ; Nana A. Ansah ; Myron M. Levine ; Kristen Lewis ; Michele L. Coia ; Margaret Attah-Poku ; Joel Ojwando ; Stephen B. Rivers ; John C. Victor ; Geoffrey Nyambane ; Abraham Hodgson ; Florian Schödel ; Max Ciarlet ; Kathleen M. NeuzilSource :
- Lancet (London, England) [ 1474-547X ] ; 2010.
Descripteurs français
- KwdFr :
- Administration par voie orale, Afrique subsaharienne, Anticorps antiviraux (sang), Calendrier vaccinal, Gastroentérite (), Gastroentérite (virologie), Humains, Immunoglobuline A (sang), Indice de gravité médicale, Infections à rotavirus (), Infections à rotavirus (immunologie), Méthode en double aveugle, Nourrisson, Pays en voie de développement, Rotavirus (immunologie), Vaccins anti-rotavirus (administration et posologie), Vaccins anti-rotavirus (immunologie), Vaccins atténués (administration et posologie), Vaccins atténués (immunologie).
- MESH :
- administration et posologie : Vaccins anti-rotavirus, Vaccins atténués.
- immunologie : Infections à rotavirus, Rotavirus, Vaccins anti-rotavirus, Vaccins atténués.
- sang : Anticorps antiviraux, Immunoglobuline A.
- virologie : Gastroentérite.
- Administration par voie orale, Afrique subsaharienne, Calendrier vaccinal, Gastroentérite, Humains, Indice de gravité médicale, Infections à rotavirus, Méthode en double aveugle, Nourrisson, Pays en voie de développement.
English descriptors
- KwdEn :
- Administration, Oral, Africa South of the Sahara, Antibodies, Viral (blood), Developing Countries, Double-Blind Method, Gastroenteritis (prevention & control), Gastroenteritis (virology), Humans, Immunization Schedule, Immunoglobulin A (blood), Infant, Rotavirus (immunology), Rotavirus Infections (immunology), Rotavirus Infections (prevention & control), Rotavirus Vaccines (administration & dosage), Rotavirus Vaccines (immunology), Severity of Illness Index, Vaccines, Attenuated (administration & dosage), Vaccines, Attenuated (immunology).
- MESH :
- chemical , administration & dosage : Rotavirus Vaccines, Vaccines, Attenuated.
- chemical , blood : Antibodies, Viral, Immunoglobulin A.
- chemical , immunology : Rotavirus Vaccines, Vaccines, Attenuated.
- geographic : Africa South of the Sahara.
- immunology : Rotavirus, Rotavirus Infections.
- prevention & control : Gastroenteritis, Rotavirus Infections.
- virology : Gastroenteritis.
- Administration, Oral, Developing Countries, Double-Blind Method, Humans, Immunization Schedule, Infant, Severity of Illness Index.
Abstract
Rotavirus gastroenteritis causes many deaths in infants in sub-Saharan Africa. Because rotavirus vaccines have proven effective in developed countries but had not been tested in developing countries, we assessed efficacy of a pentavalent rotavirus vaccine against severe disease in Ghana, Kenya, and Mali between April, 2007, and March, 2009.
DOI: 10.1016/S0140-6736(10)60889-6
PubMed: 20692030
Affiliations:
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Le document en format XML
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<term>Africa South of the Sahara</term>
<term>Antibodies, Viral (blood)</term>
<term>Developing Countries</term>
<term>Double-Blind Method</term>
<term>Gastroenteritis (prevention & control)</term>
<term>Gastroenteritis (virology)</term>
<term>Humans</term>
<term>Immunization Schedule</term>
<term>Immunoglobulin A (blood)</term>
<term>Infant</term>
<term>Rotavirus (immunology)</term>
<term>Rotavirus Infections (immunology)</term>
<term>Rotavirus Infections (prevention & control)</term>
<term>Rotavirus Vaccines (administration & dosage)</term>
<term>Rotavirus Vaccines (immunology)</term>
<term>Severity of Illness Index</term>
<term>Vaccines, Attenuated (administration & dosage)</term>
<term>Vaccines, Attenuated (immunology)</term>
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<term>Afrique subsaharienne</term>
<term>Anticorps antiviraux (sang)</term>
<term>Calendrier vaccinal</term>
<term>Gastroentérite ()</term>
<term>Gastroentérite (virologie)</term>
<term>Humains</term>
<term>Immunoglobuline A (sang)</term>
<term>Indice de gravité médicale</term>
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<term>Infections à rotavirus (immunologie)</term>
<term>Méthode en double aveugle</term>
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<term>Pays en voie de développement</term>
<term>Rotavirus (immunologie)</term>
<term>Vaccins anti-rotavirus (administration et posologie)</term>
<term>Vaccins anti-rotavirus (immunologie)</term>
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<term>Vaccines, Attenuated</term>
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<term>Vaccins anti-rotavirus</term>
<term>Vaccins atténués</term>
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<term>Indice de gravité médicale</term>
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<front><div type="abstract" xml:lang="en">Rotavirus gastroenteritis causes many deaths in infants in sub-Saharan Africa. Because rotavirus vaccines have proven effective in developed countries but had not been tested in developing countries, we assessed efficacy of a pentavalent rotavirus vaccine against severe disease in Ghana, Kenya, and Mali between April, 2007, and March, 2009.</div>
</front>
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<affiliations><list><country><li>Ghana</li>
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<name sortKey="Dallas, Michael J" sort="Dallas, Michael J" uniqKey="Dallas M" first="Michael J" last="Dallas">Michael J. Dallas</name>
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<name sortKey="Neuzil, Kathleen M" sort="Neuzil, Kathleen M" uniqKey="Neuzil K" first="Kathleen M" last="Neuzil">Kathleen M. Neuzil</name>
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<country name="Ghana"><region name="Région du Grand Accra"><name sortKey="Armah, George E" sort="Armah, George E" uniqKey="Armah G" first="George E" last="Armah">George E. Armah</name>
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